mRNA Manufacturing & QC

mRNA QC solutions for IVT, dsRNA detection, saRNA and RNA integrity analysis

Explore reagents and analytical tools for mRNA manufacturing, in-process control, and quality assessment. Dana Bioscience provides solutions for key mRNA production and QC workflows, from in vitro transcription (IVT) through purification and final RNA quality evaluation.

Our mRNA Manufacturing & QC portfolio supports the detection and monitoring of critical process-related impurities and quality attributes, including double-stranded RNA (dsRNA), residual T7 RNA polymerase, capping-related enzymes, residual DNA, and other process components.

Key Applications

  • In Vitro Transcription (IVT) process monitoring
  • dsRNA impurity detection
  • Residual T7 RNA polymerase detection
  • Capping process QC
  • Residual DNA analysis
  • RNA purity and integrity assessment
  • mRNA and saRNA manufacturing process development
  • Research and biopharmaceutical process QC

Dana Bioscience continues to expand its mRNA and saRNA QC portfolio with complementary solutions for RNA size, integrity, purity, and process-related impurity analysis.

mRNA Manufacturing Workflow

From IVT to Final RNA Quality Control

Explore analytical tools and reagents for key stages of mRNA and self-amplifying RNA (saRNA) development, manufacturing and quality control.

01 · RNA PRODUCTION

IVT & RNA Development

Tools and materials supporting in vitro transcription and the development of mRNA and long self-amplifying RNA.

mRNA · saRNA · IVT Workflow
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02 · IMPURITY QC

IVT Process Impurities

Detect important process-related impurities generated or remaining after in vitro transcription.

dsRNA · Residual T7 RNA Polymerase
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03 · PROCESS QC

Capping & Enzyme QC

Monitor residual enzymes and process components associated with mRNA synthesis and capping workflows.

Vaccinia Capping Enzyme · Inorganic Pyrophosphatase
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04 · RNA QUALITY

RNA Size & Integrity

Evaluate RNA size and integrity across conventional mRNA and long-RNA applications including saRNA.

RNA Ladders · High Range RNA Ladders · Long RNA QC
Need help selecting an mRNA QC solution? Dana Bioscience can help identify products for your specific IVT, mRNA or saRNA workflow.