ZBTB33 Antibody

Size

100ug

Clone Number

Aliases

Kaiso antibody; Kaiso protein antibody; Kaiso transcription factor antibody; KAISO_HUMAN antibody; Transcriptional regulator Kaiso antibody; ZBTB 33 antibody; Zbtb33 antibody; Zinc finger and BTB domain containing 33 antibody; Zinc finger and BTB domain-containing protein 33 antibody; Zinc finger transcription factor Kaiso antibody; ZNF 348 antibody; ZNF Kaiso antibody; ZNF348 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q86T24

Immunogen

Recombinant Human Transcriptional regulator Kaiso protein (113-228AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5\'-CGCG-3\' and also binds to the non-methylated consensus sequence 5\'-CTGCNA-3\' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ZBTB33

Research Areas

Epigenetics and Nuclear Signaling