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Upingbio
SKU:YP-Ab-18185-100UL
MSL1 rabbit pAb
MSL1 rabbit pAb
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- Gene Name: MSL1 MSL1L1
- Immunogen: Synthesized peptide derived from human MSL1
- Specificity: This antibody detects endogenous levels of MSL1 at Human, Mouse
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
- Function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure . Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) . This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 . In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation .
- Species: Human;Mouse
- Range: WB
- Protein: Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1)
- DA: 68kD
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