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Upingbio
SKU:YP-Ab-18094-100UL
METTL1 rabbit pAb
METTL1 rabbit pAb
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- Gene Name: METTL1 C12orf1
- Immunogen: Synthesized peptide derived from human METTL1
- Specificity: This antibody detects endogenous levels of METTL1 at Human, Mouse
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
- Function: Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) . Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA . Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs . Internal N(7)-methylguanine methylation of mRNAs regulates translation . Also methylates a specific subset of miRNAs, such as let-7 . N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) . Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity).
- Species: Human;Mouse
- Range: WB
- Protein: tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase)
- DA: 30kD
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