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Upingbio
SKU:YP-Ab-18092-53UL
p21(PTR2559) mouse mAb
p21(PTR2559) mouse mAb
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- Reaction species: Human;Mouse;
- Gene Name: CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
- Protein name: p21
- Molecular weight (DA): 21kD
- Immunogen: Synthesized peptide derived from human p21 AA range: 1-100
- Specificity: This antibody detects endogenous levels of p21 protein.
- Composition: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source: Mouse, Monoclonal/IgG1, kappa
- Dilution ratio: IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
- Purification process: Protein G
- Concentration: mg/ml
- Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Names: Cyclin-dependent kinase inhibitor 1 ;CDK-interacting protein 1;Melanoma differentiation-associated protein 6;MDA-6;p21;
- Function: function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.,induction:By p53, mezerein (antileukemic compound) and interferon beta.,PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.,
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