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Upingbio
SKU:YP-Ab-18024-100UL
SPO11 rabbit pAb
SPO11 rabbit pAb
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- Gene Name: SPO11
- Immunogen: Synthesized peptide derived from human SPO11
- Specificity: This antibody detects endogenous levels of SPO11 at Human, Mouse
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
- Function: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
- Species: Human;Mouse
- Range: WB
- Protein: Meiotic recombination protein SPO11 (Cancer/testis antigen 35) (CT35)
- DA: 44kD
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