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Upingbio
SKU:YP-Ab-18005-100UL
CNOT8 rabbit pAb
CNOT8 rabbit pAb
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- Gene Name: CNOT8 CALIF POP2
- Immunogen: Synthesized peptide derived from human CNOT8
- Specificity: This antibody detects endogenous levels of CNOT8 at Human, Mouse
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
- Function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity
- Species: Human;Mouse
- Range: WB
- Protein: CCR4-NOT transcription complex subunit 8 (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8)
- DA: 32kD
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