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Upingbio
SKU:YP-Ab-17919-100UL
TMEM175 rabbit pAb
TMEM175 rabbit pAb
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- Gene Name: TMEM175
- Immunogen: Synthesized peptide derived from human TMEM175
- Specificity: This antibody detects endogenous levels of TMEM175 at Human, Mouse,Rat
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
- Function: Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes . Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion . Constitutes the major lysosomal potassium channel . Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors . The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation . The lysoK(GF) complex is required to protect neurons against stress-induced damage .
- Species: Human;Mouse;Rat
- Range: WB
- Protein: Transmembrane protein 175
- DA: 55kD
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