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Upingbio
SKU:YP-Ab-17909-100UL
HDAC6 (3B2) Mouse mAb
HDAC6 (3B2) Mouse mAb
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- Reaction species: Human,Rat
- Gene Name: HDAC6
- Molecular weight (DA): Calculated MW: 131 kDa; Observed MW: 160 kDa
- Immunogen: Purified recombinant human HDAC6 protein expressed in E.coli.
- Dilution ratio: WB: 1/500-1/1000
- Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Other Names: HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6
- Background: Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
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