• ULK1 Rabbit mAb
1 1

Upingbio

YP-Ab-17898-53UL

ULK1 Rabbit mAb

ULK1 Rabbit mAb

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Size
  • Reaction species: Human,Mouse,Rat
  • Gene Name: ULK1
  • Molecular weight (DA): Calculated MW: 113 kDa; Observed MW: 120 kDa
  • Immunogen: synthesized peptide derived from human ULK1
  • Dilution ratio: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
  • Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Other Names: ULK1; KIAA0722; Serine/threonine-protein kinase ULK1; Autophagy-related protein 1 homolog; ATG1; hATG1; Unc-51-like kinase 1
  • Background: Act as a convergence point for multiple signals that control autophagy, and can bind to several autophagy-related (Atg) proteins, regulating phosphorylation states and protein trafficking. AMPK, activated during low nutrient conditions, directly phosphorylates ULK1 at multiple sites including Ser317, Ser555, and Ser777. Conversely, mTOR, which is a regulator of cell growth and an inhibitor of autophagy, phosphorylates ULK1 at Ser757 and disrupts the interaction between ULK1 and AMPK.
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