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Upingbio
SKU:YP-Ab-17892-100UL
DMRT1 rabbit pAb
DMRT1 rabbit pAb
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- Gene Name: DMRT1 DMT1
- Immunogen: Synthesized peptide derived from human DMRT1. AA range:330-373
- Specificity: This antibody detects endogenous levels of DMRT1 at Human, Mouse
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
- Function: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play
- Species: Human;Mouse
- Range: WB
- Protein: Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1)
- DA: 41kD
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