• PI3 Kinase p110 alpha Rabbit mAb
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Upingbio

YP-Ab-17844-53UL

PI3 Kinase p110 alpha Rabbit mAb

PI3 Kinase p110 alpha Rabbit mAb

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Size
  • Reaction species: Human,Mouse,Rat
  • Gene Name: PIK3CA
  • Molecular weight (DA): Calculated MW: 124 kDa; Observed MW: 110 kDa
  • Immunogen: synthesized peptide derived from human PI 3 Kinase catalytic subunit alpha
  • Dilution ratio: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
  • Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Other Names: phosphatidylinositol-4; 5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; PI3-kinase p110 alpha; PI3K; PI3K p110-alpha; PK3CA; PtdIns-3-kinase p110
  • Background: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.
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