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Upingbio
SKU:YP-Ab-17825-53UL
Caspase 11 Rabbit mAb
Caspase 11 Rabbit mAb
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- Reaction species: Human,Mouse,Rat
- Gene Name: Casp4
- Molecular weight (DA): Calculated MW: 43 kDa; Observed MW: 43,38,25 kDa
- Immunogen: Recombinant protein of mouse Caspase-11
- Dilution ratio: WB: 1/500-1/1000 IP: 1/20
- Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Other Names: Caspl; ich-3; CASP-4; Casp11; CASP-11
- Background: Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators.
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