• AMPK Gamma 1 Mouse mAb
1 1

Upingbio

YP-Ab-17811-53UL

AMPK Gamma 1 Mouse mAb

AMPK Gamma 1 Mouse mAb

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Size
  • Reaction species: Human,Rat
  • Gene Name: PRKAG1
  • Molecular weight (DA): Calculated MW: 38 kDa; Observed MW:38 kDa
  • Immunogen: Peptide
  • Dilution ratio: WB：1/500-1/1000
  • Storage: Store at -20°C. Avoid freeze/thaw cycles.
  • Other Names: AMPKg, PRKAG1
  • Background: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
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