• Fetal Hemoglobin Rabbit mAb
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Upingbio

YP-Ab-17698-53UL

Fetal Hemoglobin Rabbit mAb

Fetal Hemoglobin Rabbit mAb

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Size
  • Reaction species: Human
  • Gene Name: HBG1/HBG2
  • Molecular weight (DA): Calculated MW: 16 kDa; Observed MW: 12 kDa
  • Immunogen: synthesized peptide derived from human HBG1/2
  • Dilution ratio: WB: 1/500-1/1000
  • Concentration: mg/ml
  • Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Background: The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008],
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