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Upingbio
SKU:YP-Ab-17689-100UL
CNOT3 rabbit pAb
CNOT3 rabbit pAb
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- Gene Name: CNOT3 KIAA0691 LENG2 NOT3
- Immunogen: Synthesized peptide derived from human CNOT3
- Specificity: This antibody detects endogenous levels of CNOT3 at Human, Mouse
- Composition: Liquid in PBS containing 50% glycerol, and 0.582% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: ‘-15°C to -25°C/1 year(Do not lower than -25°C)
- Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
- Species: Human;Mouse
- Range: WB
- Protein: CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2)
- DA: 83kD
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