• Cytokeratin 19 mouse mAb(ABT050)
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Upingbio

YP-Ab-17641-53UL

Cytokeratin 19 mouse mAb(ABT050)

Cytokeratin 19 mouse mAb(ABT050)

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  • Reaction species: Human
  • Gene Name: KRT19
  • Protein name: CK19
  • Immunogen: Synthesized peptide derived from human CK19
  • Specificity: The antibody can specifically recognize human CK19 protein, and shows no cross reaction with CK1, 5, 6, 7, 8, 10, 13, 14, 15, 17, 18, 20.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.67% sodium azide.
  • Source: Mouse, Monoclonal/IgG2b, Kappa
  • Dilution ratio: IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Storage: -20°C/1 year
  • Other Names: Keratin, type I cytoskeletal 19 (Cytokeratin-19;CK-19;Keratin-19;K19)
  • Background: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008],
  • Function: developmental stage:Present in hair follicles at all stages of development.,domain:This keratin differs from all other IF proteins in lacking the C-terminal tail domain.,function:Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.,tissue specificity:Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestin
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