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SKU:YP-Ab-17284-100UL
PHF8 rabbit pAb
PHF8 rabbit pAb
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- Gene Name: PHF8 KIAA1111 ZNF422
- Immunogen: Synthesized peptide derived from human C-ternal PHF8
- Specificity: This antibody detects endogenous levels of PHF8 at Human, Mouse
- Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source: Rabbit,polyclonal
- Dilution ratio: WB 1:500-2000 IHC 1:50-200
- Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8)
- Function: Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity
- Species: Human, Mouse
- Range: IHC,WB
- Protein: Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8)
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