• WWP1 rabbit pAb
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YP-Ab-17276-100UL

WWP1 rabbit pAb

WWP1 rabbit pAb

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  • Gene Name: WWP1
  • Immunogen: Synthesized peptide derived from human N-ternal WWP1
  • Specificity: This antibody detects endogenous levels of WWP1 at Human, Mouse
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Rabbit,polyclonal
  • Dilution ratio: WB 1:500-2000 IHC 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (Atrophin-1-interacting protein 5) (AIP5) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
  • Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
  • Species: Human, Mouse
  • Range: IHC,WB
  • Protein: NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (Atrophin-1-interacting protein 5) (AIP5) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
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