• MCLN1 rabbit pAb
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Upingbio

YP-Ab-17275-100UL

MCLN1 rabbit pAb

MCLN1 rabbit pAb

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  • Gene Name: MCOLN1 ML4 MSTP080
  • Immunogen: Synthesized peptide derived from human N-ternal MCLN1
  • Specificity: This antibody detects endogenous levels of MCLN1 at Human, Mouse
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Rabbit,polyclonal
  • Dilution ratio: WB 1:500-2000 IHC 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Mucolipin-1 (MG-2) (Mucolipidin)
  • Function: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy . Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events . By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels .
  • Species: Human, Mouse
  • Range: IHC,WB
  • Protein: Mucolipin-1 (MG-2) (Mucolipidin)
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