1
/
of
1
Upingbio
SKU:YP-Ab-17254-100UL
TET2 rabbit pAb
TET2 rabbit pAb
Regular price
$0.00 USD
Regular price
Sale price
$0.00 USD
Unit price
/
per
Shipping calculated at checkout.
Couldn't load pickup availability
- Gene Name: TET2 KIAA1546 Nbla00191
- Immunogen: Synthesized peptide derived from human C-ternal TET2
- Specificity: This antibody detects endogenous levels of TET2 at Human, Mouse
- Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source: Rabbit,polyclonal
- Dilution ratio: WB 1:500-2000 IHC 1:50-200
- Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
- Function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
- Species: Human, Mouse
- Range: IHC,WB
- Protein: Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
- DA: 220kD
Share
