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SKU:YP-Ab-17232-100UL
K1199 rabbit pAb
K1199 rabbit pAb
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- Gene Name: KIAA1199
- Immunogen: Synthesized peptide derived from human C-ternal K1199
- Specificity: This antibody detects endogenous levels of K1199 at Human, Mouse
- Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source: Rabbit,polyclonal
- Dilution ratio: WB 1:500-2000 IHC 1:50-200
- Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: Protein KIAA1199
- Function: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
- Species: Human, Mouse
- Range: IHC,WB
- Protein: Protein KIAA1199
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