• Nrf2 (PTR2557) Mouse mAb
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Upingbio

YP-Ab-17147-100UL

Nrf2 (PTR2557) Mouse mAb

Nrf2 (PTR2557) Mouse mAb

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  • Reaction species: Human, Mouse,Rat
  • Gene Name: NFE2L2 NRF2
  • Protein name: Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)
  • Molecular weight (DA): 75-100kD
  • Immunogen: Synthesized peptide derived from human Nrf2
  • Specificity: This antibody detects endogenous levels of Nrf2 at Human, Mouse,Rat
  • Composition: PBS, pH7.4, 50% glycerol, 0.03%Proclin 300
  • Source: Mouse,monoclonal:IgM, Kappa
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: Protein G
  • Storage: -20°C/1 year
  • Other Names: Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)
  • Background: nuclear factor, erythroid 2 like 2(NFE2L2) Homo sapiens This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015],
  • Function: domain:Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.,function:Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.,PTM:Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. CNC subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electr
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