• IGSF4B Polyclonal Antibody
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Upingbio

YP-Ab-17026-100UL

IGSF4B Polyclonal Antibody

IGSF4B Polyclonal Antibody

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  • Gene Name: CADM3
  • Immunogen: The antiserum was produced against synthesized peptide derived from human CADM3. AA range:141-190
  • Specificity: IGSF4B Polyclonal Antibody detects endogenous levels of IGSF4B protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: CADM3; IGSF4B; NECL1; SYNCAM3; TSLL1; Cell adhesion molecule 3; Brain immunoglobulin receptor; Immunoglobulin superfamily member 4B; IgSF4B; Nectin-like protein 1; NECL-1; Synaptic cell adhesion molecule 3; SynCAM3; TSLC1-like protein 1; TS
  • Background: cell adhesion molecule 3(CADM3) Homo sapiens IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008],
  • Function: domain:The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.,function:Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.,induction:Markedly in glioma cell lines and prostate cancer cell lines.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Localized at the cell-cell attached sites of the plasma membrane.,subunit:Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK.,tissue specificity:Isoform 1 is expressed mainly in adult and fetal brain.
  • Species: Human;Mouse;Rat
  • Range: WB;IHC;IF;ELISA
  • Protein: Cell adhesion molecule 3
  • DA: 43kD
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