• PDLIM5 (phospho Tyr251) Polyclonal Antibody
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YP-Ab-16885-100UL

PDLIM5 (phospho Tyr251) Polyclonal Antibody

PDLIM5 (phospho Tyr251) Polyclonal Antibody

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  • Gene Name: PDLIM5
  • Immunogen: Synthesized phospho-peptide around the phosphorylation site of human PDLIM5 (phospho Tyr251)
  • Specificity: Phospho-PDLIM5 (Y251) Polyclonal Antibody detects endogenous levels of PDLIM5 protein only when phosphorylated at Y251.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: PDLIM5; ENH; L9; PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein
  • Background: This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012],
  • Function: caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:May play a role in genetic susceptibility to schizophrenia. PDLIM5 is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.,function:May play an important role in the heart development by scaffolding PKC to the Z-disk region.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 3 LIM zinc-binding domains.,subunit:Interacts with various PKC isoforms through the LIM domains. Interacts with actin and alpha-actinin through the PDZ domain.,tissue specificity:Heart and skeletal muscle specific.,
  • Species: Human;Rat;Mouse;
  • Range: WB;ELISA;IHC
  • Protein: PDZ and LIM domain protein 5
  • DA: 64kD
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