• VE-Cadherin mouse Monoclonal Antibody(3G8)
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Upingbio

YP-Ab-16863-53UL

VE-Cadherin mouse Monoclonal Antibody(3G8)

VE-Cadherin mouse Monoclonal Antibody(3G8)

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Size
  • Reaction species: Human;Mouse;Rat
  • Gene Name: CDH5
  • Protein name: Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
  • Molecular weight (DA): 80-115kD
  • Immunogen: Synthetic Peptide of VE-Cadherin
  • Specificity: The antibody detects endogenous VE-Cadherin protein
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: IHC-p 1:50-300. IF 1:50-200
  • Purification process: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: Cadherin-5 (7B4 antigen;Vascular endothelial cadherin;VE-cadherin;CD antigen CD144)
  • Background: This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015],
  • Function: function:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.,similarity:Contains 5 cadherin domains.,subcellular location:Found at cell-cell boundaries and probably at cell-matrix boundaries.,tissue specificity:Endothelial tissues and brain.,
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