• Collagen IV α2 (Cleaved-Ser1485) rabbit pAb
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YP-Ab-16812-100UL

Collagen IV α2 (Cleaved-Ser1485) rabbit pAb

Collagen IV α2 (Cleaved-Ser1485) rabbit pAb

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  • Gene Name: COL4A2
  • Immunogen: Synthesized peptide derived from human Collagen IV α2 (Cleaved-Ser1485)
  • Specificity: This antibody detects endogenous levels of Human,Mouse Collagen IV α2 (Cleaved-Ser1485, protein was cleaved amino acid sequence between 1485-1486 )
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:1000-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Collagen alpha-2(IV) chain [Cleaved into: Canstatin]
  • Background: domain:Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.,function:Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,PTM:The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.,PTM:Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.,similarity:Belongs to the type IV collagen family.,similarity:Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.,subunit:There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.,
  • Function: negative regulation of angiogenesis, extracellular matrix organization, extracellular structure organization, regulation of angiogenesis,
  • Species: Human;Mouse
  • Range: WB; ELISA
  • Protein: Collagen IV α2 (Cleaved-Ser1485)
  • DA: 160 190kD
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