• Repo-Man Polyclonal Antibody
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Upingbio

YP-Ab-16772-100UL

Repo-Man Polyclonal Antibody

Repo-Man Polyclonal Antibody

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  • Gene Name: CDCA2
  • Immunogen: The antiserum was produced against synthesized peptide derived from human CDCA2. AA range:511-560
  • Specificity: Repo-Man Polyclonal Antibody detects endogenous levels of Repo-Man protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: CDCA2; Cell division cycle-associated protein 2; Recruits PP1 onto mitotic chromatin at anaphase protein; Repo-Man
  • Background: cell division cycle associated 2(CDCA2) Homo sapiens This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
  • Function: function:Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.,PTM:Phosphorylated by CDK1. May regulate its subcellular location.,subcellular location:Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.,subunit:Interacts with PPP1CC.,tissue specificity:Ubiquitously expressed.,
  • Species: Human
  • Range: WB;IHC;IF;ELISA
  • Protein: Cell division cycle-associated protein 2
  • DA: 120-130kD
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