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Upingbio
SKU:YP-Ab-16689-100UL
Cdc5L Polyclonal Antibody
Cdc5L Polyclonal Antibody
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- Gene Name: CDC5L
- Immunogen: The antiserum was produced against synthesized peptide derived from human CDC5L. AA range:721-770
- Specificity: Cdc5L Polyclonal Antibody detects endogenous levels of Cdc5L protein.
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: CDC5L; KIAA0432; PCDC5RP; Cell division cycle 5-like protein; Cdc5-like protein; Pombe cdc5-related protein
- Background: The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008],
- Function: disease:A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.,function:DNA-binding protein involved in cell cycle control. May act as a transcription activator. Also seems to be involved in the second catalytic step of pre-mRNA splicing.,PTM:Phosphorylated; which enhances interaction with PPP1R8.,similarity:Belongs to the CEF1 family.,similarity:Contains 2 HTH myb-type DNA-binding domains.,subcellular location:May shuttle between cytoplasm and nucleus.,subunit:Homodimer. Interacts with DAPK3 (By similarity). Binds to DNA. Binds to adeno-pre-mRNA in an ATP-stimulated manner. Belongs to the spliceosome complex. Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Identified in the spliceosome C complex, at least composed
- Species: Human;Mouse;Rat
- Range: IHC;IF;ELISA
- Protein: Cell division cycle 5-like protein
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