• Cdc25C (phospho Ser198) Polyclonal Antibody
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YP-Ab-16635-100UL

Cdc25C (phospho Ser198) Polyclonal Antibody

Cdc25C (phospho Ser198) Polyclonal Antibody

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  • Gene Name: CDC25C
  • Immunogen: The antiserum was produced against synthesized peptide derived from human CDC25C around the phosphorylation site of Ser198. AA range:164-213
  • Specificity: Phospho-Cdc25C (S198) Polyclonal Antibody detects endogenous levels of Cdc25C protein only when phosphorylated at S198.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: CDC25C; M-phase inducer phosphatase 3; Dual specificity phosphatase Cdc25C
  • Background: cell division cycle 25C(CDC25C) Homo sapiens This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015],
  • Function: catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed predominantly in G2 phase.,function:Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.,PTM:Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase.,similarity:Belongs to the MPI phosphatase family.,similarity:Contains 1 rhodanese domain.,subunit:Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.,
  • Species: Human;Rat;Mouse;
  • Range: IHC;IF;ELISA
  • Protein: M-phase inducer phosphatase 3
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