• HCN2 Polyclonal Antibody
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Upingbio

YP-Ab-16429-100UL

HCN2 Polyclonal Antibody

HCN2 Polyclonal Antibody

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  • Gene Name: HCN2
  • Immunogen: The antiserum was produced against synthesized peptide derived from human HCN2. AA range:491-540
  • Specificity: HCN2 Polyclonal Antibody detects endogenous levels of HCN2 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: HCN2; BCNG2; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; Brain cyclic nucleotide-gated channel 2; BCNG-2
  • Background: Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010],
  • Function: domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.,miscellaneous:Inhibited by extracellular cesium ions.,similarity:Belongs to the potassium channel HCN family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2.,tissue specificity:Highly expressed throughout the brain. Detected at
  • Species: Human;Mouse;Rat
  • Range: WB;IHC;IF;ELISA
  • Protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
  • DA: 100kD
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