• CLC-4 Polyclonal Antibody
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Upingbio

YP-Ab-16399-100UL

CLC-4 Polyclonal Antibody

CLC-4 Polyclonal Antibody

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  • Gene Name: CLCN4
  • Immunogen: The antiserum was produced against synthesized peptide derived from human CLCN4. AA range:221-270
  • Specificity: CLC-4 Polyclonal Antibody detects endogenous levels of CLC-4 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: CLCN4; H(+)/Cl(-) exchange transporter 4; Chloride channel protein 4; ClC-4; Chloride transporter ClC-4
  • Background: chloride voltage-gated channel 4(CLCN4) Homo sapiens The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012],
  • Function: function:Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.,miscellaneous:The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.,similarity:Belongs to the chloride channel (TC 2.A.49) family.,similarity:Contains 2 CBS domains.,tissue specificity:Abundant in skeletal muscle and also detectable in brain and heart.,
  • Species: Human;Mouse;Rat
  • Range: WB;IF;ELISA
  • Protein: H(+)/Cl(-) exchange transporter 4
  • DA: 85kD
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