• HSC 70 Polyclonal Antibody
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Upingbio

YP-Ab-16281-100UL

HSC 70 Polyclonal Antibody

HSC 70 Polyclonal Antibody

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  • Gene Name: HSPA8
  • Immunogen: Synthesized peptide derived from the Internal region of human HSC 70. AA range: 588-638
  • Specificity: The antibody detects endogenous HSC 70 protein.
  • Composition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000.IHC-p:1:50-300.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Storage: -20°C/1 year
  • Other Names: HSPA8; HSC70; HSP73; HSPA10; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
  • Background: This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],
  • Function: function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous.,
  • Species: Human;Mouse;Rat
  • Range: WB;IHC;IF
  • Protein: Heat shock cognate 71 kDa protein
  • DA: 70-72kD
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