• REP-2 Polyclonal Antibody
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Upingbio

YP-Ab-16233-100UL

REP-2 Polyclonal Antibody

REP-2 Polyclonal Antibody

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  • Gene Name: CHML
  • Immunogen: The antiserum was produced against synthesized peptide derived from human CHML. AA range:128-177
  • Specificity: REP-2 Polyclonal Antibody detects endogenous levels of REP-2 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: CHML; REP2; Rab proteins geranylgeranyltransferase component A 2; Choroideraemia-like protein; Rab escort protein 2; REP-2
  • Background: The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008],
  • Function: function:Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family.,miscellaneous:Substitutes for REP-1 thereby preventing widespread tissue abnormalities in patients with choroideremia who lack REP-1.,similarity:Belongs to the Rab GDI family.,subunit:Monomer. Interacts with Rab and Rab GGTase.,
  • Species: Human
  • Range: WB;IHC;IF;ELISA
  • Protein: Rab proteins geranylgeranyltransferase component A 2
  • DA: 85kD
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