• MUM1 mouse mAb(ABT080)
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Upingbio

YP-Ab-15606-53UL

MUM1 mouse mAb(ABT080)

MUM1 mouse mAb(ABT080)

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  • Reaction species: Human; Predict react with Mouse, Rat
  • Gene Name: IRF4 MUM1
  • Protein name: MUM1
  • Immunogen: Synthesized peptide derived from human MUM1
  • Specificity: The antibody can specifically recognize human MUM1 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.168% sodium azide.
  • Source: Mouse, Monoclonal/IgG1, Kappa
  • Dilution ratio: IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Storage: -20°C/1 year
  • Other Names: Interferon regulatory factor 4 (IRF-4;Lymphocyte-specific interferon regulatory factor;LSIRF;Multiple myeloma oncogene 1;NF-EM5)
  • Background: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],
  • Function: disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.,function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,
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