• Caldesmon pan mouse mAb(ABT125)
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Upingbio

YP-Ab-15539-53UL

Caldesmon pan mouse mAb(ABT125)

Caldesmon pan mouse mAb(ABT125)

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  • Reaction species: Human
  • Gene Name: CALD1 CAD CDM
  • Protein name: Caldesmon pan
  • Immunogen: Synthesized peptide derived from human Caldesmon pan
  • Specificity: The antibody can recognize human h-caldesmon and l-caldesmon protein. In western blotting , the antibody labels a 93KDa band.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.165% sodium azide.
  • Source: Mouse, Monoclonal/IgG2a, Kappa
  • Dilution ratio: IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Storage: -20°C/1 year
  • Other Names: Caldesmon (CDM)
  • Background: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],
  • Function: domain:The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.,function:Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping.,PTM:In non-muscle cells, phosphorylation by CDC2 during mit
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