• Cytokeratin 18 rabbit mAb(ABT165R)
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Upingbio

YP-Ab-15509-53UL

Cytokeratin 18 rabbit mAb(ABT165R)

Cytokeratin 18 rabbit mAb(ABT165R)

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  • Reaction species: Human
  • Gene Name: KRT18 CYK18 PIG46
  • Protein name: Cytokeratin 18
  • Immunogen: Synthesized peptide derived from human Cytokeratin 18
  • Specificity: This antibody detects endogenous levels of Cytokeratin 18 at Human
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC-p 1:50. IF 1:50-200
  • Purification process: The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
  • Storage: -20°C/1 year
  • Other Names: Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein;Cytokeratin-18;CK-18;Keratin-18;K18)
  • Function: disease:Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600].,function:Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.,induction:By IL-6.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.,PTM:Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.,PTM:Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either
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