• CD61 rabbit mAb(ABT134R)
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Upingbio

YP-Ab-15502-53UL

CD61 rabbit mAb(ABT134R)

CD61 rabbit mAb(ABT134R)

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  • Reaction species: Human
  • Gene Name: ITGB3 GP3A
  • Protein name: CD61
  • Immunogen: Synthesized peptide derived from human CD61
  • Specificity: This antibody detects endogenous levels of CD61 at Human
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC-p 1:200. IF 1:50-200
  • Purification process: The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
  • Storage: -20°C/1 year
  • Other Names: Integrin beta-3 (Platelet membrane glycoprotein IIIa;GPIIIa;CD antigen CD61)
  • Function: disease:Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors.,function:Int
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