• Claudin 18 mouse mAb(ABT158)
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Upingbio

YP-Ab-15097-100UL

Claudin 18 mouse mAb(ABT158)

Claudin 18 mouse mAb(ABT158)

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  • Reaction species: Human
  • Gene Name: CLDN18 UNQ778/PRO1572
  • Protein name: Claudin 18
  • Immunogen: Synthesized peptide derived from human Claudin 18
  • Specificity: The antibody can specifically recognize both human Claudin 18.1 and Claudin 18.2 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.155% sodium azide.
  • Source: Mouse,Monoclonal
  • Dilution ratio: IHC-p 1:100-500, IF 1:100-500
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Storage: -20°C/1 year
  • Other Names: Claudin-18
  • Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010],
  • Function: function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,tissue specificity:Concentrated at the cell-cell borders of epithelial cells.,
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