• PI 3-Kinase p110γ Polyclonal Antibody
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Upingbio

YP-Ab-14914-100UL

PI 3-Kinase p110γ Polyclonal Antibody

PI 3-Kinase p110γ Polyclonal Antibody

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  • Gene Name: PIK3CG
  • Immunogen: The antiserum was produced against synthesized peptide derived from human PIK3CG. AA range:881-930
  • Specificity: PI 3-Kinase p110γ Polyclonal Antibody detects endogenous levels of PI 3-Kinase p110γ protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: PIK3CG; Phosphatidylinositol 4; 5-bisphosphate 3-kinase catalytic subunit gamma isoform; PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit
  • Background: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015],
  • Function: catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.,enzyme regulation:Activated by both the alpha and the beta-gamma G proteins.,function:3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.,pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.,tissue specificity:Pancreas, skeletal muscle, liver and heart.,
  • Species: Human;Rat;Mouse;
  • Range: WB;IHC;IF;ELISA
  • Protein: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • DA: 120kD
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