• Dyrk1B Polyclonal Antibody
1 1

Upingbio

YP-Ab-14735-100UL

Dyrk1B Polyclonal Antibody

Dyrk1B Polyclonal Antibody

$0.00 USD
$0.00 USD
Sale Sold out
Shipping calculated at checkout.
Size
  • Gene Name: DYRK1B
  • Immunogen: The antiserum was produced against synthesized peptide derived from human DYR1B. AA range:331-380
  • Specificity: Dyrk1B Polyclonal Antibody detects endogenous levels of Dyrk1B protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: DYRK1B; MIRK; Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Minibrain-related kinase; Mirk protein kinase
  • Background: This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
  • Function: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Inhibited by RANBP9.,function:Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.,PTM:Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5.,tissue specificity:Highest expression in skeletal muscle, testis, heart and brain with little expressio
  • Species: Human;Mouse
  • Range: WB;IHC;IF;ELISA
  • Protein: Dual specificity tyrosine-phosphorylation-regulated kinase 1B
  • DA: 70kD
View full details