• CARKL Polyclonal Antibody
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Upingbio

YP-Ab-14693-100UL

CARKL Polyclonal Antibody

CARKL Polyclonal Antibody

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  • Gene Name: SHPK
  • Immunogen: The antiserum was produced against synthesized peptide derived from human CARKL. AA range:31-80
  • Specificity: CARKL Polyclonal Antibody detects endogenous levels of CARKL protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: SHPK; CARKL; Sedoheptulokinase; SHK; Carbohydrate kinase-like protein
  • Background: sedoheptulokinase(SHPK) Homo sapiens The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008],
  • Function: catalytic activity:ATP + sedoheptulose = ADP + sedoheptulose 7-phosphate.,disease:Deficiency of the SHPK gene in cystinosis patients with a common 57-Kb deletion causes urinary accumulation of sedoheptulose and erythritol.,similarity:Belongs to the FGGY kinase family.,tissue specificity:Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.,
  • Species: Human;Mouse;Rat
  • Range: WB;IHC;IF;ELISA
  • Protein: Sedoheptulokinase
  • DA: 55kD
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