• Brk Polyclonal Antibody
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Upingbio

YP-Ab-14680-100UL

Brk Polyclonal Antibody

Brk Polyclonal Antibody

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  • Gene Name: PTK6
  • Immunogen: The antiserum was produced against synthesized peptide derived from human Breast Tumor Kinase. AA range:402-451
  • Specificity: Brk Polyclonal Antibody detects endogenous levels of Brk protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: PTK6; BRK; Protein-tyrosine kinase 6; Breast tumor kinase; Tyrosine-protein kinase BRK
  • Background: protein tyrosine kinase 6(PTK6) Homo sapiens The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012],
  • Function: catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,enzyme regulation:Activated enzyme seems to have greater access to its substrates.,function:Phosphorylates KHDRBS1, KHDRBS2, KHDRBS3 and STAP2/BKS. May function as an intracellular signal transducer in epithelial tissues. Overexpression in mammary cells leads to mitogenically sensitization to EGF, and results in a partially transformed phenotype. Its presence in the nucleus appears to be linked to suppression of tumor progression.,PTM:Autophosphorylated. The phosphorylation of Tyr-447 may lead to the autoinhibition of the enzyme.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Colocalizes with KHDRBS1, KHDRBS2 o
  • Species: Human;Rat;Mouse;
  • Range: IF;ELISA
  • Protein: Protein-tyrosine kinase 6
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