• IRAK-1 (phospho Thr387) Polyclonal Antibody
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YP-Ab-14574-100UL

IRAK-1 (phospho Thr387) Polyclonal Antibody

IRAK-1 (phospho Thr387) Polyclonal Antibody

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  • Gene Name: IRAK1
  • Immunogen: The antiserum was produced against synthesized peptide derived from human IRAK1 around the phosphorylation site of Thr387. AA range:353-402
  • Specificity: Phospho-IRAK-1 (T387) Polyclonal Antibody detects endogenous levels of IRAK-1 protein only when phosphorylated at T387.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000;IHC-p 1:50-300
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: IRAK1; IRAK; Interleukin-1 receptor-associated kinase 1; IRAK-1
  • Background: This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
  • Function: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.,PTM:Autophosphorylated or is transphosphorylated by IRAK4 following recruitment to the IL-1RI. In the case of isoform 1, this is linked to ubiquitination and degradation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.,similarity:
  • Species: Human;Mouse;Rat
  • Range: WB;IHC
  • Protein: Interleukin-1 receptor-associated kinase 1
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