• phospho-MLKL (S358) mouse Monoclonal Antibody(6F8)
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Upingbio

YP-Ab-14260-53UL

phospho-MLKL (S358) mouse Monoclonal Antibody(6F8)

phospho-MLKL (S358) mouse Monoclonal Antibody(6F8)

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Size
  • Reaction species: Human
  • Gene Name: MLKL
  • Protein name: MLKL
  • Molecular weight (DA): 54kD
  • Immunogen: Synthetic Peptide of phospho-MLKL (S358)
  • Specificity: phospho-MLKL (S358) protein detects endogenous levels of MLKL
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: IF: 1:50-200 IHC 1:100-200
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: MLKL
  • Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
  • Function: domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
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