• LC3B mouse Monoclonal Antibody(9H5)
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Upingbio

YP-Ab-14258-53UL

LC3B mouse Monoclonal Antibody(9H5)

LC3B mouse Monoclonal Antibody(9H5)

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  • Reaction species: Human;Bovine
  • Gene Name: MAP1LC3B
  • Protein name: MAP1LC3B
  • Molecular weight (DA): 14,16kD
  • Immunogen: Recombinant Protein of LC3B of MAP1LC3B
  • Specificity: LC3B protein detects endogenous levels of MAP1LC3B
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000. IF 1:50-200
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: MAP1LC3B
  • Background: The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008],
  • Function: caution:PubMed:12740394 has shown that the protein is cleaved at Lys-122 but PubMed:15355958 has shown that the cleavage site is at Gly-120 as in other mammalian orthologs.,function:Probably involved in formation of autophagosomal vacuoles (autophagosomes).,PTM:The precursor molecule is cleaved by APG4B/ATG4B to form LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form LC3-II.,similarity:Belongs to the MAP1 LC3 family.,subcellular location:LC3-II binds to the autophagic membranes.,subunit:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.,tissue specificity:Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver.,
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