• CaMKIV mouse mAb
1 1

Upingbio

YP-Ab-14219-10UL

CaMKIV mouse mAb

CaMKIV mouse mAb

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Size
  • Reaction species: Human
  • Gene Name: camk4
  • Molecular weight (DA): 55kD
  • Immunogen: Purified recombinant human CaMKIV protein fragments expressed in E.coli.
  • Specificity: This antibody detects endogenous levels of CaMKIV and does not cross-react with related proteins.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: wb 1:1000
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: Brain Ca(2 ) calmodulin dependent protein kinase type 4;Brain Ca(2 ) calmodulin dependent protein kinase type IV;Brain Ca -calmodulin dependent protein kinase type IV;Calcium / calmodulin dependent protein kinase type 4 catalytic chain;Calcium / calmodulin dependent protein kinase type IV catalytic chain; Calcium/calmodulin dependent protein kinase IV;Calcium/calmodulin dependent protein kinase type IV;Calcium/calmodulin-dependent protein kinase type IV;CAM kinase 4;CAM kinase GR;CAM kinase IV;CAM kinase-GR;CaMK 4;CAMK GR;CaMK IV;CaMK4;CaMKGR;IV;KCC4_HUMAN; MGC36771.
  • Background: The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008],
  • Function: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. Autophosphorylation of the N-terminus is required for full activation. In part, activity is independent on Ca(2+)/calmodulin and autophosphorylation of Ser-336 allows to switch to a Ca(2+)/calmodulin-independent state (By similarity). Probably inactivated by serine/threonine protein phosphatase 2A.,function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role i
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