• PP1β Monoclonal Antibody
1 1

Upingbio

YP-Ab-14201-53UL

PP1β Monoclonal Antibody

PP1β Monoclonal Antibody

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  • Reaction species: Human;Mouse;Rat;Chicken;Dog;Pig
  • Gene Name: PPP1CB
  • Protein name: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
  • Immunogen: Purified recombinant human PP1β protein fragments expressed in E.coli.
  • Specificity: PP1β Monoclonal Antibody detects endogenous levels of PP1β protein.
  • Composition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
  • Source: Monoclonal, Mouse
  • Dilution ratio: Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
  • Purification process: Affinity purification
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: PPP1CB; Serine/threonine-protein phosphatase PP1-beta catalytic subunit; PP-1B; PPP1CD
  • Background: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
  • Function: catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,domain:The C-terminus is required for CDK2-activation, but not CDK2-binding.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity.,function:Regulates the G1/S phase transition of the cell cycle by binding and activating CDC2, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process throug
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