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Upingbio
SKU:YP-Ab-14074-100UL
CD155 Polyclonal Antibody
CD155 Polyclonal Antibody
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- Gene Name: PVR
- Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human PVR. AA range:81-130
- Specificity: CD155 Polyclonal Antibody detects endogenous levels of CD155 protein.
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: PVR; PVS; Poliovirus receptor; Nectin-like protein 5; NECL-5; CD155
- Background: The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],
- Function: function:Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to
- Species: Human;Mouse;Rat
- Range: WB IF;ELISA
- Protein: Poliovirus receptor
- DA: 70kD
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