• CD42d/GPV Polyclonal Antibody
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Upingbio

YP-Ab-14055-100UL

CD42d/GPV Polyclonal Antibody

CD42d/GPV Polyclonal Antibody

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  • Gene Name: GP5
  • Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human GP5. AA range:331-380
  • Specificity: CD42d Polyclonal Antibody detects endogenous levels of CD42d protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: GP5; Platelet glycoprotein V; GPV; Glycoprotein 5; CD42d
  • Background: Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010],
  • Function: function:The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.,PTM:The N-terminus is blocked.,similarity:Contains 14 LRR (leucine-rich) repeats.,tissue specificity:Platelets and megakaryocytes.,
  • Species: Human;Mouse;Rat
  • Range: WB;IHC;IF;FC,ELISA
  • Protein: Platelet glycoprotein V
  • DA: 62kD
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